Can ivermectin treat covid-19

[Mike J]

This is the least biased article that I have located concerning the use of ivermectin to treat covid-19.  I expect that many, perhaps most, have already made a determination as to it's use.  I say "least biased" because I think people on either side of the fence concerning its use will see it as supporting their decision to use it, not use it, or "wait and see".  

https://www.msn.com/en-us/news/technology/can-ivermectin-treat-covid-19-what-you-should-know-about-this-controversial-drug/ar-AALXFB8

Spoiler

 

Doctors desperate for an answer to the COVID-19 problem early in the pandemic began reviewing whether any already available drug could be used as an effective treatment. Ivermectin, an anti-parasitic, was administered to some patients across the globe, with seemingly positive effects. However, some health officials have challenged the effectiveness of the drug to treat COVID-19, creating controversy in both the medical and political spheres. 

text, letter: There are a lot of questions, and arguments, about ivermectin. Getty Images© Provided by CNET There are a lot of questions, and arguments, about ivermectin. Getty Images
text, letter: There are a lot of questions, and arguments, about Ivermectin.© Getty Images
There are a lot of questions, and arguments, about Ivermectin.

On one side, there are doctors who say ivermectin can help end the pandemic if used globally. On the other are public health officials who have reviewed the data and say the drug's effectiveness against COVID-19 isn't conclusive.

Here's everything you need to know about ivermectin and its use for COVID-19. 

What is ivermectin?
Ivermectin is an anti-parasitic medicine "that works by altering cellular channels," said Dr. Soumi Eachempati, CEO of Cleared4 and former professor of surgery and public health at Weill Cornell Medical College. The drug inhibits some viruses from infecting cells, thus preventing the virus from spreading. Ivermectin is usually given to treat parasitic infections like lice and Strongyloides, according to Eachempati. 

Scientists at pharmaceuticals giant Merck discovered ivermectin in 1975 and began to use it to treat scabies, river blindness and other parasitic diseases carried by worms and lice starting in 1981. It's on the World Health Organization's list of essential medicines for a basic health care system. More than 250 million people take the drug across the globe each year, and it's effective for animals as well.

The drug is considered safe when taken in appropriate dosages. Side effects for the ivermectin vary depending on whether it's taken orally to treat intestinal infections or topically for skin infections. Oral tablets can cause drowsiness, nausea, vomiting and, in very rare cases, an increase in heart rate and seizures. Side effects for the topical ivermectin can include skin rash and irritation, while dry skin and stinging pain are severe and rare.

Can ivermectin be used to treat COVID-19?
This is where things get complicated. Public health agencies, including the Federal Drug Administration, the National Institutes of Health and the World Health Organization, don't suggest ivermectin's use to treat COVID-19. They cite the lack of data from large, randomized trials confirming the drug's effectiveness to treat the disease. 

Doctors who cited multiple smaller studies and firsthand experience say otherwise. They claim ivermectin does work to prevent people from developing symptoms from COVID-19 and can shorten recovery time for those already infected.  

What do the public health agencies say about ivermectin use for COVID-19 treatment?
The FDA said in March it hasn't approved the use of ivermectin to treat COVID-19. It warned that large doses of the drug are "dangerous and can cause serious harm." The agency also advised against human use of ivermectin produced for animals, such as cows and horses, as the doses aren't the same and could contain ingredients intended only for animals. 

There has been a growing number of people taking ivermectin for animals as word spread on social media about its possible use to cure COVID-19. This has resulted in some people calling state poison centers after taking the incorrect dosage since the medication is intended for animals.

In April, the FDA reaffirmed in a post on its website that ivermectin isn't approved to treat COVID-19 nor has it been given emergency use authorization. 

The NIH said in February there was insufficient data to "recommend either for or against the use of ivermectin for the treatment of COVID-19." It did say lab tests found the drug stopped the reproduction of the SARS-CoV-2 virus that cause the disease. However, to be effective, the dosages would need to be "100-fold higher than those approved for use in humans." 

While some clinical studies showed ivermectin to have no benefit, the NIH said others saw a lower mortality rate among patients. However, those studies were incomplete or had methodological limitations such as small sample sizes or patients receiving additional medicine along with ivermectin, according to the NIH. 

The WHO said in March the current evidence on the use of ivermectin for treatment of COVID-19 was "inconclusive." 

Who says ivermectin is a treatment, and what information do they have? 
Ivermectin's potential use as a COVID-19 therapeutic made headway last December during a Senate Homeland Security Committee meeting called Focus on Early Treatment of COVID-19. Dr. Pierre Kory, a pulmonary and critical care specialist, testified about the drug's usage for treatment of the disease. 

Video player from: YouTube (Privacy Policy, Terms)
"Ivermectin is highly safe, widely available, and low cost," Kory said in the Senate meeting. "We now have data from over 20 well-designed clinical studies, 10 of them randomized, controlled trials, with every study consistently reporting large magnitude and statistically significant benefits in decreasing transmission rates, shortening recovery times, decreasing hospitalizations, or large reductions in deaths. These data show that ivermectin is effectively a 'miracle drug' against COVID-19." 

During his testimony, Kory referred to a paper he authored -- Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19 -- that was published in the May edition of the American Journal of Therapeutics. 

The paper was also included in the Frontiers of Pharmacology journal in January but was then removed in March. Dr. Frederick Fenter, chief executive editor of the journal, said the paper was removed due to "strong, unsupported claims based on studies with insufficient statistical significance, and at times, without the use of control groups." Fender also said the authors promoted their own specific ivermectin-based treatment, which goes against editorial policies. 

A study listed in Kory's paper involved giving ivermectin to 234 uninfected health care workers in Argentina and found those who received the drug were far less likely to be diagnosed with COVID. For mildly ill patients, an Iraq study saw a quicker recovery time. 

There are also studies that show otherwise. A clinical trial of 476 patients found ivermectin didn't improve the recovery time in patients who had COVID-19. A review of 10 random clinical trials, with more than 1,000 participants, also didn't find improvements with ivermectin. One Egyptian study claimed to show positive results, but it's since been redacted over ethical concerns.

Merck, the company that discovered ivermectin, released a statement in February saying there was "no scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies" and "no meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease." It also cited a lack of safety data from major studies. 

Why is there controversy over ivermectin?
The debate about ivermectin's usage to treat COVID-19 has gone from the hospital to social media, exacerbating the discourse as well as the vitriol. While those in support of the drug appear to want an end to the pandemic, their arguments in favor of ivermectin have become fodder for anti-vaxxers and conspiracy theorists. 

Groups that have spread misinformation about COVID-19 throughout the pandemic latched onto ivermectin's usage following Kory's Senate testimony. Anti-vax groups on Telegram share misinformation about the vaccine while asking where they can buy the drug. Rumble, an alternative video platform to YouTube, has pages of videos falsely saying vaccines are ineffective while advising people to also take ivermectin. 

a person sitting on a bed: One study on the effectiveness of ivermectin took place at the Center for Pediatric Infectious Diseases Studies, in Cali, Colombia. Luis Robayo/AFP via Getty Images© Provided by CNET One study on the effectiveness of ivermectin took place at the Center for Pediatric Infectious Diseases Studies, in Cali, Colombia. Luis Robayo/AFP via Getty Images
Anti-vax posts and videos can also be found on YouTube, Facebook and Twitter, although the companies are attempting to take these posts down or make them harder to find. 

Kory was a guest on the Dark Horse Podcast hosted by Bret Weinstein, a former professor at Evergreen State College, on June 1 to talk about ivermectin. That video was eventually demonetized on YouTube and Weinstein's channel received a strike, which prevented him from posting content for one week and could lead to its removal if he receives two more strikes within 90 days. 

YouTube says its actions on Weinstein's videos were part of its policies. 

"While we welcome open discussions of potential treatments and clinical trials related to COVID-19 on YouTube, based on guidance from the CDC, FDA and other local health authorities, we don't currently allow content that recommends ivermectin as an effective treatment or prevention method for the virus," said Ivy Choi, a YouTube spokesperson. "We craft our policies to prevent the risk of egregious real-world harm, and update them as official guidance evolves. We do allow exceptions to our policy about ivermectin, including content that also gives viewers the full context of the FDA's current position."

Because of YouTube's decision, the controversy over ivermectin grew and became tied to what some claim to be "big tech censorship." 

What is required for ivermectin to get approved for COVID-19 treatment? 
For the public health agencies, it's going to come down to the results of large clinical studies being conducted around the world. 

"In the UK, it was announced that ivermectin will be added to the Principle Trial, a large clinical study designed to assess potential COVID therapies for non-hospitalized therapies for patients at higher risk for severe disease," said Dr. David Shafran, head of pediatrics at telehealth app K Health. "This should demonstrate more definitively the efficacy of ivermectin in early-stage COVID infections. Fingers crossed because it's a cheap medication with a good safety profile. It would be great to add this to the armament of medication to fight COVID."

The Oxford University Principle Trial has more than 5,000 participants and will give a three-day course of oral ivermectin treatment to individuals randomly and compare their results to individuals who will receive standard care. 

In the US, the NIH is evaluating therapeutics for COVID-19 with its Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) master protocol. ivermectin was added in phase three of ACTIV-6, which will test the effectiveness of repurposed drugs. 

"The ACTIV prioritization group, trial team and trial oversight groups continuously track new data on any agent we are studying in our trials and evaluate that data for how it might influence our testing of that agent and the safety/well being of the participants in the trial," said Dr. Sarah Dunsmore, a program director at the National Center for Advancing Translational Sciences that is part of the NIH. 

What's unclear is how long the whole process will take. The studies need time to be completed, and then the agencies will require additional time to come up with decisions based on the data.

 

 

[scott h]

1 hour ago, Mike J said:

I expect that many, perhaps most, have already made a determination as to it's use. 

Here are my thoughts. When my car breaks down, I take it to a mechanic. My internet goes down, I call the service provider. If I feel like sushi...I go to a Japanese restaurant, not a Mexican restaurant. 

If I trust my Doctor (why would I go to him/her if I didn't) and they prescribed it, down the hatch it goes. End of story as far as I am concerned.

What I find interesting in the article is:

On one side, there are doctors who say ivermectin can help end the pandemic if used globally. On the other are public health officials who have reviewed the data and say the drug's effectiveness against COVID-19 isn't conclusive.

IMHO I would side with a qualified Doctor and not an unnamed "public health official" 

 

[RBM]

31 minutes ago, scott h said:

Here are my thoughts. When my car breaks down, I take it to a mechanic. My internet goes down, I call the service provider. If I feel like sushi...I go to a Japanese restaurant, not a Mexican restaurant. 

If I trust my Doctor (why would I go to him/her if I didn't) and they prescribed it, down the hatch it goes. End of story as far as I am concerned.

What I find interesting in the article is:

On one side, there are doctors who say ivermectin can help end the pandemic if used globally. On the other are public health officials who have reviewed the data and say the drug's effectiveness against COVID-19 isn't conclusive.

IMHO I would side with a qualified Doctor and not an unnamed "public health official" 

 

Each to their own I guess,

This is one of Doc Campbells numerous videos on the subject, big Pharma have not managed to stop it.

 

[Snowy79]

I think the fact that to date none of the so called success stories have even undergone a fraction of the investigations that vaccines have and none of the trials complied with the requirements for assessing new medicines I'll just wait on the real studies to be published and peer reviewed.

The other trials as they explain have been peer reviewed and rubbished so let's see what happens when proper tests are carried out. The same experts will be free to pick those trials apart. 

[Joey G]

Deciding to use it (assuming it's available) probably depends on the situation you're in (how sick)... a one gallon empty jug is far from being considered a life preserver in the water, but in some instances I'd hold on to it for dear life.  

[Reboot]

Quote

Can ivermectin treat covid-19

There is a good deal of evidence it can help. I know only one thing: it does a decent job of deworming my chickens.

[DaveB]

There's a few hundred miliion people being vaccinated with extremely small instances of adverse reaction.  There's ivermectine which has a "hey, try this" following.

So...on one hand, free vaccine with a track record...on the other hand someting else that "might be helpful".  Seems to me with the effort to go get some ivermectine you could just go get vaccinated and not worry about it.  Why bother with ivermectine?  Just because you can...maybe?

[hk blues]

1 hour ago, DaveB said:

There's a few hundred miliion people being vaccinated with extremely small instances of adverse reaction.  There's ivermectine which has a "hey, try this" following.

So...on one hand, free vaccine with a track record...on the other hand someting else that "might be helpful".  Seems to me with the effort to go get some ivermectine you could just go get vaccinated and not worry about it.  Why bother with ivermectine?  Just because you can...maybe?

Some folk just have an aversion to using the vaccines as they are produced by the big bad Pharma guys.   Others always like to swim against the tide.  Others again are suspicious of mainstream "stuff" in general.  

Each to their own.   

[Snowy79]

I've been seeing a few warnings coming up on CNN Philippines saying there are many cases of people overdosing on animal Invermectin in the States. Probably hoping for a different kind of " HERD" immunity. I'll get my coat.  

[Mike J]

10 hours ago, Snowy79 said:

I've been seeing a few warnings coming up on CNN Philippines saying there are many cases of people overdosing on animal Invermectin in the States. Probably hoping for a different kind of " HERD" immunity. I'll get my coat.  

Fortunately I did not have a mouthful of coffee when I read your post.